Noninvasive delivery of gene therapeutics to the central nervous system
Our lab utilizes transcranial focused ultrasound to achieve transient, focal perturbation of the blood–brain barrier, enabling delivery of molecular therapies to the central nervous system. This incisionless approach eliminates the need for invasive surgery and allows for reversible modulation of gene products. Our goal is to establish a noninvasive platform for the delivery, detection, and modulation of gene products across the central nervous system.
Circuit Development
Our lab is interested in how circuits relevant to complex cognitive dynamics develop from a young age with the purpose of informing biomarkers for neurodevelopmental disorders. To that end, we’re developing noninvasive techniques to track structural and functional brain development longitudinally.
Cross Species Comparability
Our lab is interested in how circuits relevant to complex cognitive dynamics develop from a young age with the purpose of informing biomarkers for neurodevelopmental disorders. We are interested in the extent to which functional and structural organization of the brain is similar or different across species, with a keen interest in the implications these analogies have for modeling human brain diseases. Through the use of modern imaging and analysis techniques, we can gain a better understanding of how evolution has influenced brain architecture.
Connectomics of the Primate Brain
We are big proponents of open science and strive to make all of our data publicly accessable in a format that can readily inform hypotheses about brain functional and structural connectivity.
Our Marmoset Brain Connectome project does just that, and is actively updated as data is acquired.